When these anti-glycan IgG antibodies bind to abnormal IgA1, immune complexes are formed.

当这些抗糖基化的IgG抗体与异常IgA1结合，形成免疫合物。

And these are known as anti-glycan IgG antibodies.

这些就是抗糖基化的IgG抗体。

In response, the body generates IgG antibodies that target the abnormally glycosylated residues.

在免疫应答下，机体产生针对异常糖基化残基的IgG抗体。

Meanwhile, IgG antibodies circulate for an extended period after infection;their presence usually indicates that someone was exposed and recovered.

同时，IgG抗体在感染后很长时间，它们的存在常表明有人被感染并。

Immunoassays may detect IgG antibodies, the most abundant class, and IgM antibodies, the type that's first produced in response to a new infection.

免疫测定可以检测 IgG 抗体（最丰富的一类）和 IgM 抗体（应对新感染而首先产生的抗体）。

In these sorts of infections, IgA1 antibody production gets ramped up, leading to IgG anti-glycan formation, and immune complex deposition in the glomerular mesangium, causing inflammation.

在这些感染情况下，IgA1抗体产生增多，导致抗糖基化的抗体IgG形成，免疫合物便沉积在肾小球系膜，产生炎症反应。

These centroblasts have a rearrangement of their immunoglobulin genes, and some of them undergo a class switch where they change from producing IgM antibodies to producing IgG or IgA antibodies.

这部分中心母细胞的免疫球蛋白基因发生了重排，其中的一些经历Ig类别转换，从产生IgM变成产生IgG或IgA。

When the abnormal IgA1-IgG immune complexes deposit in the mesangium, the alternative complement pathway is activated, leading to the release of proinflammatory cytokines and migration of macrophages into the kidney, all of which contributes to glomerular injury.

当异常的IgA1-IgG免疫合物沉积在系膜上时，补体旁路途径被激活，导致促炎因子的释放，同时促进巨噬细胞向肾迁移，以上所有反应导致肾小球的损伤。

So combining IgG or IgM, a positive on either and looking at just 20 days or more of having illness you can see that only one test actually captured everybody, that was the test from BioPerfectus.

因此结合IgG或IgM，任何一个呈现阳性并且只看20天及以上的患病情况，你发现只有一个测试真正检测出了每个病例，那就是来自BioPerfectus（江苏硕世）的测试。