Tetany, epilepsy, neuro-psychiatrical symptoms, hypocalcemia, hyperphosphatemia were common clinical manifestation.There was also low level of PTH, except pseudohypoparathyroidism.
These results suggest that early neonatal hopocalcemia appears to be related to a transient lack of response to PTH of the target organs, disordered vitamin D metabolism and hypercalcitoninemia.
Bone remodelling as a whole is highly dependent on serum calcium levels, which, in turn, are kept in the normal range by a balance between parathyroid hormone, or PTH, calcitonin and vitamin D.