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1.Randomized aldactone evaluation study (RALES) showed that adding aldosterone antagonist in the treatment of heart failure may decrease 30% mortality of all causes.

1.随机螺内酯评估研究表明在心力醛甾酮拮抗药可使总死亡率降低30%。

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Osmosis-泌尿

1.An important hormone that helps regulate potassium reabsorption or secretion in the kidneys is aldosterone.

肾脏中一种帮助调节钾重吸收或分泌重要激素叫醛固酮

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Osmosis-泌尿

2.Other pathological conditions that cause increased aldosterone levels include compensated heart failure and cirrhosis.

其他导致醛固酮增加病理状况包括代偿期心衰和肝硬化。

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Osmosis-内分泌

3.With these medications around, aldosterone can't exert its effects.

有了这些药物,醛固酮就无法发挥其作用了。

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Osmosis-心血管

4.Another example is a tumor that produces excess aldosterone, which just like renin, leads to fluid retention.

另一个例子生长也会产生过多醛固酮一种类似于肾素物质,会导致积存。

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WIL生活启示录

5.Aldosterone has it's purpose, but it's not a hormone you want to regularly have high levels of.

醛固酮有其作用,但在人体中,这种荷尔蒙不能太高。

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Osmosis-内分泌

6.Aldosterone is part of a hormone family or axis which work together and are called the renin-angiotensin-aldosterone system.

醛固酮属于一特定激素家族或激素轴一部分,这些激素共同作用,被称为肾素-血管紧张素-醛固酮系统。

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WIL生活启示录

7.But, as I mentioned earlier, this renin angiotensin aldosterone system is stimulated by low salt intake.

,正如我之前提到,低盐饮食会导致 RAA 系统活跃。

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Osmosis-内分泌

8.The diagnosis of hyperaldosteronism is mainly done by measuring levels of renin and aldosterone.

醛固酮增多症诊断主要通过测定肾素与醛固酮来完成

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Osmosis-泌尿

9.Now, an important hormone that helps regulate potassium reabsorption or secretion in the kidneys is aldosterone.

所以,肾脏中有一种重要激素可以帮助调节钾重吸收和分泌,这就醛固酮

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Osmosis-内分泌

10.Secondary causes of hyperaldosteronism are usually due to excess aldosterone production in response to high levels of renin.

醛固酮增多症继发性原因通常由于高肾素导致醛固酮生成过多。

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Osmosis-内分泌

11.So in this case aldosterone levels are high and renin levels are low in.

因此,在这种情况下,醛固酮较高,肾素较低。

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WIL生活启示录

12.As this study shows, a low salt diet increases aldosterone by more than 3 fold in healthy people.

这项研究显示,健康正常人采用低盐饮食,其体内醛固酮将增加 3 倍有余。

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WIL生活启示录

13.This suggests that people actually following the WHO guidelines are chronically raising their aldosterone.

也就说,遵循世卫组织关于盐摄入量建议人们,他们体内醛固酮长期处于较高

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WIL生活启示录

14.High aldosterone is associated with increased inflammation, Chronic kidney disease, Osteoporosis, and cardiovascular disease.

醛固酮会增加体内炎症,导致慢性肾病、骨质疏松症以及心血管疾病。

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WIL生活启示录

15.These drugs inhibit Angiotensin Converting Enzyme, hindering an important step in the RAA system resulting in lower aldosterone and lower blood pressure.

这种药物通过抑制血管紧张素转化酶作用(RAA 系统关键作用之一),以达到降低醛固酮及血压

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Osmosis-内分泌

16.Hyperaldosteronism can happen due to primary causes which is where the adrenal gland itself is responsible for the excess production of aldosterone.

醛固酮增多症可以原发性,即肾上腺本身产生了过量醛固酮

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WIL生活启示录

17.Another study shows that when salt intake drops below 1.5 teaspoons per day, a significant increase in renin and aldosterone occurs.

另一项研究显示,当盐摄入量降至每天 1.5 茶匙以下,人体中醛固酮及肾素将大幅上升。

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WIL生活启示录

18.On the flip side of aldosterone, there is a group of hormones called natriuretic hormones, i. e. sodium urinating hormones.

醛固酮另一面有一组激素叫利钠激素,也就钠尿荷尔蒙。

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Osmosis-泌尿

19.Aldosterone increases sodium channels on the lumen side of the principal cell and sodium-potassium pumps on the basolateral side of the principal cells.

它增加主细胞腔面钠离子、钾离子通道和基底面钠-钾泵数量。

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Osmosis-内分泌

20.The other function of aldosterone is to stimulate the ATPase pumps in alpha-intercalated cells which causes more protons to get excreted into the urine.

醛固酮另一个功能刺激α-闰细胞上ATP酶泵(H+-K+-ATP酶)使更多氢离子排泄到尿中。

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