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Randomized aldactone evaluation study (RALES) showed that adding aldosterone antagonist in the treatment of heart failure may decrease 30% mortality of all causes.

随机螺内酯究表明在心力衰竭治中加用醛甾酮拮抗药死亡率降低30%。

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Osmosis-心血管

Another example is a tumor that produces excess aldosterone, which just like renin, leads to fluid retention.

个例子是肿瘤的生也会产生过多的醛固酮,种类似于肾素的物质,会导致液体的积存。

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High aldosterone is associated with increased inflammation, Chronic kidney disease, Osteoporosis, and cardiovascular disease.

高醛固酮水平会增加体内炎症,导致慢性肾病、骨质疏松症以及心血管疾病。

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This suggests that people actually following the WHO guidelines are chronically raising their aldosterone.

也就是说,遵循世卫组织关于盐建议的人们,他们体内的醛固酮期处于较高水平。

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Osmosis-泌尿

Now, an important hormone that helps regulate potassium reabsorption or secretion in the kidneys is aldosterone.

所以,肾脏种重要的激素可以帮助调节钾的重吸收和分泌,这就是醛固酮。

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Aldosterone has it's purpose, but it's not a hormone you want to regularly have high levels of.

醛固酮有其作用,但在人体,这种荷尔蒙的水平不能太高。

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Osmosis-内分泌

Aldosterone is part of a hormone family or axis which work together and are called the renin-angiotensin-aldosterone system.

醛固酮属于特定激素家族或激素轴的部分,这些激素共同作用,被称为肾素-血管紧张素-醛固酮系统。

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Osmosis-泌尿

An important hormone that helps regulate potassium reabsorption or secretion in the kidneys is aldosterone.

肾脏种帮助调节钾重吸收或分泌的重要激素叫醛固酮。

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But, as I mentioned earlier, this renin angiotensin aldosterone system is stimulated by low salt intake.

但是,正如我之前提到的,低盐饮食会导致 RAA 系统活跃。

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Osmosis-内分泌

The diagnosis of hyperaldosteronism is mainly done by measuring levels of renin and aldosterone.

醛固酮增多症的诊断主要通过测定肾素与醛固酮的水平来完成。

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Osmosis-内分泌

Less aldosterone floating around in the blood causes the body to start dumping sodium from the blood into the urine.

醛固酮减少使得尿钠排出增多。

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Osmosis-内分泌

So in this case aldosterone levels are high and renin levels are low in.

因此,在这种情况下,醛固酮水平较高,肾素水平较低。

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As this study shows, a low salt diet increases aldosterone by more than 3 fold in healthy people.

这项研究显示,健康正常人采用低盐饮食,其体内醛固酮水平将增加 3 倍有余。

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Osmosis-内分泌

Secondary causes of hyperaldosteronism are usually due to excess aldosterone production in response to high levels of renin.

醛固酮增多症的继发性原因通常是由于高水平肾素导致醛固酮生成过多。

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Osmosis-内分泌

This taking up more space issue triggers another mechanism in our body that causes the hormone aldosterone to stop being released.

血管容的增加触发另机制造成醛固酮这激素停止释放。

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Osmosis-内分泌

With these medications around, aldosterone can't exert its effects.

有了这些药物,醛固酮就无法发挥其作用了。

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Osmosis-泌尿

Other pathological conditions that cause increased aldosterone levels include compensated heart failure and cirrhosis.

其他导致醛固酮水平增加的病理状况包括代偿期心衰和肝硬化。

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These drugs inhibit Angiotensin Converting Enzyme, hindering an important step in the RAA system resulting in lower aldosterone and lower blood pressure.

这种药物通过抑制血管紧张素转化酶的作用(RAA 系统的关键作用之),以达到降低醛固酮水平及血压的目的。

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On the flip side of aldosterone, there is a group of hormones called natriuretic hormones, i. e. sodium urinating hormones.

在醛固酮的另面,有组激素叫利钠激素,也就是钠尿荷尔蒙。

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Another study shows that when salt intake drops below 1.5 teaspoons per day, a significant increase in renin and aldosterone occurs.

项研究显示,当盐降至每天 1.5 茶匙以下,人体的醛固酮及肾素水平将大幅上升。

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Osmosis-内分泌

Hyperaldosteronism can happen due to primary causes which is where the adrenal gland itself is responsible for the excess production of aldosterone.

醛固酮增多症可以是原发性的,即肾上腺本身产生了过的醛固酮。

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