The growth,infiltration and metastasis of oncoma depend on tumor angiogenesis.Vascular endothelial growth factor(VEGF)is the most important irritant factor of angiogenesis.
Objective: To investigate the relationship of angiogenesis and microvessel density(MVD) with non-neoplastic epithelial disorders of the vulva(NNEDV) and valvar intraepithelial neoplasia(VIN).
Vascular endothelial growth factor(VEGF) is also named as vascular permeability factor(VPF),which is a powerful angiogenesis and vascular diosmosis promoter discovered at present.