In Parkinson's, these darkened areas of substantia nigra gradually disappear.

患有帕金森时，深色区域逐渐消失。

The substantia nigra actually can be split into two sub-regions.

可以被分为两个亚区：First， there’s the pars reticulata， which receives signals from another part of the basal ganglia called the striatum 纹状体， which is a term for the caudate and putamen put together， and relays messages to the thalamus via neurons rich in the neurotransmitter GABA， also known as gamma-aminobutyric acid. 首先是网状部，可以接受基底节另一部分纹状体信号；纹状体由尾状核壳核组成，可以通过富含神经递GABA神经元传递信号到丘脑，其中GABA即γ－氨基丁酸。

No matter the cause is, Parkinson's derives from the death of dopamine-producing, or dopaminergic, neurons in the substantia nigra.

无论如何，帕金森源于中生产多巴胺神经（即多巴胺能神经）亡。

One was the substantia nigra pars compacta.

一种是致密部。

Now, Parkinson's disease develops when the neurons connecting the substantia nigra to the striatum progressively degenerate.

现在，当连接神经元纹状体逐渐退化。

The misfolded alpha-synuclein aggregates to form Lewy bodies that deposit inside neurons, particularly in the cortex and the substantia nigra.

错误折叠α-突触核蛋白聚集形成路易小体，沉积在神经元中，尤其是在皮层中。

The substantia nigra is a part of the basal ganglia, a collection of brain regions that control movement through their connections with the motor cortex.

是基底节一部分；基底节是大脑几个区域集合，通过与运动皮连接控制动作。

Under a microscope, Lewy bodies, which are eosinophilic, round inclusions made of alpha-synuclein protein are present in the affected substantia nigra neurons before they die.

显微镜下，路易小体——即由α突触核蛋白构成嗜酸性包含体，可在受损神经元亡前，于细胞内被观察到。

In contrast, neurons in a section of the midbrain called the substantia nigra are in charge of initiating movement and other motor function.

相形之下，中脑有一个区域叫做，神经元负责运动设计启动以及其他运动功能。

Therefore, when substantia nigra pars compacta neurons die, the individual may be in a hypokinetic or low movement state which is commonly seen in Parkinson's.

因此，当致密部神经元亡时，患者可能会处于运动减弱状态，可常见于帕金森病。

The name substantia nigra means " black substance, " since it is darker than other brain regions when you look at a slice of the brain on an autopsy.

Substantia Nigra之所以叫“”，是因为当观察大脑尸检切片时，比大脑其他部分颜色更深。

The cortex relays sensory information as well as plans for future action, while the substantia nigra sends dopamine that helps to coordinate all of the inputs.

大脑皮层传递感觉信息未行动计划，而物送多巴胺，帮助协调所有输入。

Symptoms of Schizophrenia appear when one of the neural circuit situated in the midbrain, called Substantia nigra, overproduce neurotransmitter called Dopamine and disrupts the balance between secretion of Dopamine and Acetylcholine.

当位于中脑神经回路产生过量多巴胺，并破坏多巴胺乙酰胆碱分泌之间平衡时，就会出现精神分裂症症状。

In addition to simply initiating movements, the substantia nigra helps to calibrate and fine tune the way that movements happen, which leads to the clinical features of Parkinson's.

在引动作阶段，可以参与微调校准动作生，这就可以解释帕金森临床症状。

We usually refer to the substantia nigra as if it's in a single location, but there are actually two of these regions in the brain, one on each side of the midbrain.

“”听起像是指某个具体位置，但实际上是指大脑中两个区域，分别位于中脑两侧。

Brain regions such as the substantia nigra involved in reward processing or the anterior insula involved in the visceral experience of emotion or brain regions in the inferior frontal gyrus that are involved in autobiographical memories.

大脑区域，如参与奖赏处理或参与情绪内脏体验前岛叶，或参与自传体记忆额下回大脑区域。

Now, the neurons responsible for coordinating movement are located in a part of the brain called the striatum, which receives information from two major sources — the neocortex and a region known as the substantia nigra.

现在，负责协调运动神经元位于大脑一部分被称为纹状体，它接收自两个主要源信息-大脑皮层大脑皮层被称为区域。