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Furthermore, PTP1B deletion significantly reduced gene expression of 3 1-adrenergic receptor subtypes, consistent with blunted constriction to phenylephrine.

PTP1B缺乏明显减少31-肾上腺受体亚型基因表达,与对苯福林收缩反应迟钝有关。

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HPLC method for determination of phenylephrine hydrochloride, paracetamol, caffeine anhydrous,salicylamide and brompheniramine maleate in Liufenkamin tablets was established.

立了HPLC法测定柳酚咖敏片中盐酸去氧肾上腺素、对乙氨基酚、无咖啡因、胺、马来酸溴苯那敏的含量。

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Vox

We'll make phenylephrine red because we know it leaves you congested.

我们会让苯肾上腺素的成像变红,因为我们知道它会让你充

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Vox

But I didn't know there was anything wrong with phenylephrine.

但我不知道苯肾上腺素有什么问题。

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当月 科学60秒-科学美国

So, the committee voted unanimously that oral phenylephrine is basically useless.

因此,委员会一致认为口服苯肾上腺素并无缓解鼻塞的功效。

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Vox

" 10 milligrams of phenylephrine works no better than a placebo."

“10 毫克苯肾上腺素的效果并不比安慰剂好。”

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当月 科学60秒-科学美国

Overall, though, if oral phenylephrine doesn't work, what should people use instead of it?

总的来说,如果口服苯肾上腺素不起,还有什么更好的替代品吗?

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当月 科学60秒-科学美国

Scientists who advise the FDA recently concluded that phenylephrine, a common decongestant in cold medicines, doesn't work.

美国食品和药品管理局(FDA)的顾问科学家最近得出结论:感冒药中常见的减充剂苯肾上腺素不起

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Vox

It led to further similarly conclusive studies that phenylephrine was ineffective.

这导致了进一步类似的结论性研究,即苯肾上腺素是无效的。

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当月 科学60秒-科学美国

One of the most popular decongestant ingredients is phenylephrine.

减充剂最常见成分之一是苯肾上腺素。

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当月 科学60秒-科学美国

She was on the recent FDA advisory panel earlier this month that made the decision that phenylephrine wasn't effective.

她是本月早些时候做出苯肾上腺素无效决定的FDA顾问小组的专家。

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Vox

The take-home messages are oral phenylephrine is inaffective as a nasal decongestant but safe.

带回家的信息是口服苯肾上腺素为减充剂是无效的,但安全。

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当月 科学60秒-科学美国

Exactly. In addition to that, three trials of oral phenylephrine showed it was no better than a placebo at relieving congestion.

确实如此。除此之外,口服苯肾上腺素的三项试验表明,这种成分在缓解充方面并不比安慰剂好。

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科学快报-科学美国Science Quickly, from SCIENTIFIC AMERICAN

They didn't review phenylephrine nasal sprays.

刘易斯:他们没有审查去氧肾上腺素鼻喷雾剂。

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当月 科学60秒-科学美国

Exactly. So, more products started using phenylephrine.

没错。于是更多的产品开始使苯肾上腺素。

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Vox

Where nasal congestion went down after taking pseudoephedrine and went like this for a placebo and phenylephrine.

伪麻黄碱后鼻塞减轻,服安慰剂和苯肾上腺素后鼻塞也减轻。

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Vox

They have known for decades that phenylephrine might not really work and it's just the process that's gotten in the way.

他们几十年前就知道苯肾上腺素可能并没有真正起,只是这个过程阻碍了治疗。

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Vox

And the panelists voting, they seemed a little mystified by how we got to a point where phenylephrine took over.

小组成员投票时,他们似乎有困惑,为什么我们会走到苯肾上腺素占据主导地位的地步。

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当月 科学60秒-科学美国

And I always look to see if a decongestant like phenylephrine is in the capsule.

我总是看胶囊成分,是否含有像苯肾上腺素这样的减充剂。

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Vox

Taken from an FDA Zoom meeting these are the votes of FDA panel members on whether phenylephrine is effective.

摘自 FDA Zoom 会议这些是 FDA 小组成员对苯肾上腺素是否有效的投票。

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当月 科学60秒-科学美国

They didn't review phenylephrine nasal sprays. Those might still be effective since they are going right into your nose.

他们没有审查苯肾上腺素鼻腔喷雾剂的功效。这些成分可能仍然有效,因为它们直接进入了鼻腔。

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科学快报-科学美国Science Quickly, from SCIENTIFIC AMERICAN

Fischman: Overall, though, if oral phenylephrine doesn't work, what should people use instead of it?

Fischman:不过,总的来说,如果口服去氧肾上腺素不起们应该什么来代替它?

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