When something causes an increased expression of degradative enzymes, then the balance tips toward a net loss of cartilage, via loss of proteoglycans and collagen.

当某些因素导致分解酶表达增，和胶原纤维的损失使得平衡倾向于软骨净损失。

They initially start making less of the proteoglycans and more Type II collagen, but soon switch over to making a different collagen type, type I collagen.

他们最开始形成少量的和更多的二型胶原，将很快转向产生另一类胶原：一型胶原。

Unfortunately, type I collagen doesn't interact with the proteoglycans in the same way and there is an overall decrease in elasticity in the cartilage matrix, allowing it to breakdown.

不幸的是，一型胶原并不能和正常地相互作用，导致软骨基质整体弹性减弱，容易分解。

The anchors of this framework are proteins called proteoglycans. And from each one sprouts lots and lots of long, starchy strands called glycosaminoglycans, or GAGs, radiating out from those proteins like brush bristles.

这个构架的支柱是质，并从每一个中长出许多称为胺或 GAG 的长淀粉链，从这些质中辐射出来，就像刷毛一样。