Method The target compound was synthesized from clarithromycin via hydrolyzation,acetylation,cyclic carbonatation,oxidation,decarbonatation,acylation,cyclic carbamatation and cyclization.
Deuterated perlolyrine was synthesizedstarting from deuterated tryptophan via acid-catalyzed ring-closure, aromatisationand hydrolysis, with a yield of 11.
The recent developments in conventional synthesis of naphthol are summarized, including sulfonation alkali-fusion, via isopropyl naphthalene, hydrolysis, via tetrahydronaphthalene.