This causes a decrease in CRH and ACTH, which in turn, shuts down cortisol production from the zona fasciculata.

这会降低CRH和ACTH，反过来阻止束状制造皮质醇。

The excess ACTH overstimulates zona fasciculata of both adrenal glands, which grow larger and secrete excess cortisol.

过多的ACTH会过度刺激两个肾腺的束状，使其增大并过多的皮质醇。

The zona thwarts the entry and fusion of more than one sperm, the smallest cell in the body.

阻止多个精子（体内最小的细胞） 的进入和融合。

In both adrenal adenomas and carcinomas, the cells of the zona fasciculata within the adrenal cortex start dividing abnormally and secrete excess cortisol.

在肾腺腺瘤和肾腺癌中，肾腺皮质里束状的细胞开始异常裂并过多皮质醇。

With less ACTH floating around, the zona fasciculata gets less stimulation to make cortisol, and eventually, cortisol levels go back down to the normal range again.

着ACTH减少，束状受刺激产生皮质醇减少，最后，皮质醇水平降低到正常范围内。

Second, cortisol starts cross-reacting with mineralocorticoid receptors, which normally only binds a related steroid hormone - mineralocorticoids which are secreted from the zona glomerulosa layer of the adrenal cortex.

第二，皮质醇对盐皮质激素受体产生交叉反应；此类受体一般只与一种相关的类固醇激素结合，即从肾腺皮质的球状层的盐皮质激素。

The adrenal cortex is the outer part of the adrenal gland and is subdivided into three layers- the zona glomerulosa, the zona fasciculata, and the zona reticularis.

肾腺皮质是肾腺的外层部，皮质又为三层：球状、束状和网状。

But only 100 or so will ultimately make it to the proximity of the egg, and only one will successfully penetrate through the armor of the zona pellucida.

但只有大约 100 个最终会到达卵附近，并且只有一个会成功穿的盔甲。

The most common primary cause is called idiopathic hyperaldosteronism, because the zona glomerulosa has an increase in the number of cells secreting aldosterone, but it's not really clear why this happens.

最常见的原发性病因称为特发性醛固酮增多症：这是由于球状醛固酮的细胞数量增加，但目前尚不清楚为什么会发生这种情况。

In primary hyperaldosteronism, the main problem is that zona glomerulosa cells secrete high levels of aldosterone, and that aldosterone has a negative feedback effect on renin, and so it actually inhibits renin production.

在原发性醛固酮增多症中，主要问题是球状细胞高水平的醛固酮；醛固酮对肾素有负反馈作用，因而实际抑制肾素生成。

All right, as a quick recap, hyperaldosteronism is the chronic, excess secretion of aldosterone from the zona glomerulosa of the adrenal gland, and these high aldosterone levels can lead to hypokalemia, hypernatremia, hypertension, and a metabolic alkalosis.

得！简单回顾一下：醛固酮增多症是指肾腺球状长期过多的醛固酮；这些高醛固酮水平可导致低钾血症、高钠血症、高血压与代谢性碱中毒。