Doxifluridine was facilely synthesized from 5-fluorouracil in overall yield of 54.6% via trimethyl silylation, condensation, saponification, ketal formation, iodation, hydrogenolysis and hydrolysis.
以5-氟
嘧啶为原料经硅醚化、和四乙酰核糖缩
、皂化、酮缩醇形成、碘化、氢解及水解等
成了
氧氟
。
法工艺简便、条件缓和、原料易得、成低,总收率达54.6
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