1.Method The target compound was synthesized from clarithromycin via hydrolyzation,acetylation,cyclic carbonatation,oxidation,decarbonatation,acylation,cyclic carbamatation and cyclization.

1.方法以克拉霉素为起,经水解、乙酰化、酯化、氧化、酯化、酰化、氨基甲酯化和合等反应合成目标化合物。