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This paper summarized the research advance in the live attenuated vaccine,sporozoite vaccine and DNA vaccine.

了减毒活疫、子子疫和核酸疫究进展。

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These combine and grow to become the immature form of the parasite, called a sporozoite.

这些结合并生长成为寄生虫的未成熟形式,称为子孢子。

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Then, when that mosquito bites another human, the sporozoites are injected too, and travel to the liver to hunker down, grow, and multiply.

然后,当那只蚊子叮人时, 子孢子也被注入,并移动到肝脏, 在那里留、生长和繁殖。

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Knocking out just three of the 5000 genes in the P. falciparum genome can prevent sporozoites from maturing and reproducing, so they can’t infect the bloodstream.

仅敲除恶性疟原虫因组 5000 的三,就可以阻止子孢子成熟和繁殖,因此它们无法感染血液。

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They infected mosquitoes with the genetically-engineered sporozoites and let them snack on the volunteers’ forearms. And none of the people in the trial developed malaria, so that’s good!

他们用因工程子孢子感染蚊子,让它们在志愿者的前臂上当零食。而且试验没有人患上疟疾,这很好!

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Each sporozoite produces as many as 30,000 mature parasite cells called merozoites, which spread through the bloodstream, burrow into red blood cells, and cause a full-blown infection.

子孢子产生多达 30, 000 称为裂殖子的成熟寄生虫细胞,它们通过血液传播, 钻入红细胞, 并引起全面感染。

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