3.Pyridazinone derivatives have considerable kinds of biological activities such as those cardiotonic,platelet aggregation inhibitory,anti-inflammatory,aldose reductase inhibitory,antifungal and so on.
4.OBJECTIVE: To introduce the research and development of systematic antifungal drugs such as imidazole,triazole,allylamine,antibiotic etc.and the marketing trend.
介绍咪唑类、三唑类、烯丙胺类、抗生素类等全身用抗真菌药的研发进展及市场应用趋势。
5.CONCLUSION The antifungal effect of miconazole nitrate emulsio n is strong, while mucosa irritation of its inclusion compound is not obvious.
硝酸咪康唑乳浊液的抑菌作用较强,而环包的刺激较小。
6.Here, we show that deletions of VPS28 and VPS32 increase the susceptibility of C. albicans to cell wall disruption agents, echinocandin and azole antifungal agents.
【文献摘要】Vps28p and Vps32p act in both the endocytic and the pH signaling pathways in yeasts and are required for Candida albicans virulence.